Question
After getting Skatole (that's the poop that makes all the flies love you), is it possible to get another useful item if you find a second Skull Game guy on the same playthrough? Or will it be an endless loop of keys, bombs, hearts, etc?
Answer
The Skatole is the only significant item you can acquire from the skull game. After getting the Skatole, it's an endless loop of coins, hearts, keys, and bombs. Also the occasional fly, which won't be an issue if you have the Skatole.
From the Binding of Isaac Wikia:
Shell Game: Bet 1 coin and a bomb, heart, key, coin, or the grand prize of Skatole is put under a skull and the skulls are shuffled in a manner impossible to follow.
This is also based on my repeated playthroughs.
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