Question
What runes, masteries, items, or any other aspect of the game can help defend against targets that deal true damage?
Answer
If the true damage is your only concern, you should build health items and health regen, as well as Spell vamp or Lifesteal. Also, you could use crowd control effects like Stun or knock-ups to keep the enemy from being able to hit you. Short of all that, there's not much you can do against True Damage.
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