What's the difference between the three New Game options?

Question

Deus Ex: Human Revolution gives you three options for starting a new game:

The wording seems to imply that there's more difference than just tougher enemies (i.e. more/less emphasis on story), is there?

Answer

No. "Tell me a story" does not mean that the story is enhanced. Rather, it means that the challenge is decreased, as if to say that the game is only interesting for its story and not its gameplay challenge if the player picks the reduced difficulty.

To be specific, harder difficulty decreases your health and regeneration rate, increases the enemy's health, regeneration rate and accuracy. It also affects the regeneration delay. (Source: GameFAQs)

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