Does it matter whether you use lethal or non-lethal tactics in Deus Ex: Human Revolution?

Question

Does it matter to the story?

Does it make a difference in the gameplay? E.g. with XP or whatnot.

Answer

1. According to the stealth tutorial video, a lethal takedown makes more noise than a non-lethal one.
2. Neutralizing an enemy without killing will award you a +20 XP bonus ("Merciful Soul").
3. Knocked-out guards can be woken by other guards who happen to find them. Obviously, this can't happen if they're dead.

I'm not aware of any impact on the story.

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